RNA Splicing: A New Paradigm in Host–Pathogen Interactions

1 1 RNA splicing in a new

RNA splicing in a new rhabdovirus from Culex mosquitoes.

Among members of the order Mononegavirales, RNA splicing events have been found only in the family Bornaviridae. Here, we report that a new rhabdovirus isolated from the mosquito Culex tritaeniorhynchus replicates in the nuclei of infected cells and requires RNA splicing for viral mRNA maturation. The virus, designated Culex tritaeniorhynchus rhabdovirus (CTRV), shares a similar genome organiza...

RNA Splicing: A New Player in the DNA Damage Response

It is widely accepted that tumorigenesis is a multistep process characterized by the sequential accumulation of genetic alterations. However, the molecular basis of genomic instability in cancer is still partially understood. The observation that hereditary cancers are often characterized by mutations in DNA repair and checkpoint genes suggests that accumulation of DNA damage is a major contrib...

Preface: a new universe of RNA interactions.

We now talk offhandedly of a prebiotic RNA World, a notion that was dismissed as idle and untestable speculation when proposed in the 1960s. Since then, RNA has been shown to catalyze chemical reactions, including the synthesis of the peptide bond. Small RNAs can be selected to recognize compounds with exquisite sensitivity. Even more surprising, some of these recognition events are recapitulat...

iCLIP Predicts the Dual Splicing Effects of TIA-RNA Interactions

The regulation of alternative splicing involves interactions between RNA-binding proteins and pre-mRNA positions close to the splice sites. T-cell intracellular antigen 1 (TIA1) and TIA1-like 1 (TIAL1) locally enhance exon inclusion by recruiting U1 snRNP to 5' splice sites. However, effects of TIA proteins on splicing of distal exons have not yet been explored. We used UV-crosslinking and immu...